IRT for CRC
  • Developing an Integrated Risk Prediction Tool for Colorectal Cancer
  • Cohort used for the study
  • Clinical risk factors
    • Creating the clinical dataframe
    • Creating the clinical risk model
    • Analyzing the results
  • Polygenic risk scores
    • PRSice
    • Preparing to use PRSice
    • Obtaining polygenic risk scores
    • Analyzing the results
    • Plink2
  • Integrated risk score
    • Obtaining integrated risk scores
    • Analyzing the results
  • Working with real patient data
    • Genetic data from Tempus Labs
      • Preparing the data and obtaining polygenic risk scores
      • Interpreting the scores
    • Clinical data from Gastroenterology Atlanta
      • Obtaining integrated scores and understanding the results
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Clinical risk factors

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Last updated 1 year ago

Several official sources were analyzed to come up with a possible list of risk factors for colorectal cancer including:

Risk factor
Unit of measurement
UK Biobank Field ID

Age

Years

21022

Sex

Male/female

31

Height

Inches

50

Weight

Pounds

21002

Ethnicity

UK standards

White

Physical activity

No. of days/week

884

Red meat consumption

Yes/no

1349

Smoking habits

Current, previous, never

20116

Alcohol consumption

No. of days/week

1558

Has father had cancer?

Yes/no

20107

Has mother had cancer?

Yes/no

20110

Has a sibling had cancer?

Yes/no

20111

Personal history of polyps

Yes/no

20002

Personal history of Crohn's disease

Yes/no

20002

Personal history of ulcerative colitis

Yes/no

20002

American Cancer Society (ACS)
Center for Disease Control and Prevention (CDC)
American Society of Clinical Oncology (ASCO)
Cancer Treatment Centers of America (CTCA)